Tibet, Xinjiang and Siberia (TibXS) are regions with active plate tectonics. Evidence from satellite gravimetry and altimetry shows the hydrological evolutions over these regions are sensitive to global climate change. For example, inter-annual lake level changes over Tibet and Xinjiang from satellite altimetry are found to be connected to the El Niño Southern Oscillation (ENSO). Lakes in central Asia, Xinjiang and Siberia show sharp changes in lake levels that can be explained by climate change. Recent terrestrial gravity, GRACE and GPS observations suggest that the crust over the Tibetan plateau is thickening, and the Himalayan glaciers appear to be thinning. Satellite altimetry is a potential tool to study vertical displacement and permafrost thawing and changes in the active layers in Siberia and Tibet.