We characterized E-W shortening crustal deformation using GPS measurements and an earthquake focal mechanism solution to estimate conditions before the Ms 6.5 Ludian earthquake of 3 August 2014 (16:30, UTC+8). A series of NW-SE striking transpressive faults are distributed outside the Chuan-Dian Block. They accommodated the E-W shortening and N-S stretching in this region resulting from Chuan-Dian Block outward expansion. The displacement velocity field about the eastward, fault-normal slip rate and the vertical component are also examined. The results show that they share a similar rate change at the Anninghe, Zemuhe, Puxionghe, Jiaojihe, and Baogunao-Xiaohe faults. Among these faults, the maximum thrusting slip rate of the Baogunao-Xiaohe fault is less than 4 mm yr-1. The slip rate change may represent a transition from lateral translation into a vertical thrusting movement. Furthermore, counterclockwise rotation also plays an important role in absorbing the E-W shortening. Relative to the inner zone, the outer Chuan-Dian Block together with the Daliang Shan fault zone represent the development of a new deformation area. A prediction could be made that the Daliang Shan fault zone will eventually replace the east boundary fault role of the Anninghe-Zemuhe-North Xiaojiang fault due to Chuan-Dian Block continuous outward expansion.