In this study, we used pattern informatics (PI) to visualize patterns in seismic migration for two large earthquakes in Taiwan. The 2D PI migration maps were constructed from the slope values of temporal variations of the distances between the sites and hotspot recognized from the PI map. We investigated the 2D PI migration pattern of the 1999 Chi-Chi and 2006 Pingtung earthquakes which originated from two types of seismotectonic setting. Our results show that the PI hotspots migrate toward the hypocenter only when the PI hotspots are generated from specific depth range which is associated with the seismotectonic setting. Therefore, we conclude that the spatiotemporal distribution of events prior to an impending earthquake is significantly affected by tectonics.