Using seismic activity and the Meishan earthquake sequence that occurred from 1904 to 1906, a scenario for short-term probabilistic seismic hazards in the Chiayi region of Taiwan is assessed. The long-term earthquake occurrence rate in Taiwan was evaluated using a smoothing kernel. The highest seismicity rate was calculated around the Chiayi region. To consider earthquake interactions, the rate-and-state friction model was introduced to estimate the seismicity rate evolution due to the Coulomb stress change. As imparted by the 1904 Touliu earthquake, stress changes near the 1906 Meishan and Yangshuigang epicenters was higher than the magnitude of tidal triggering. With regard to the impact of the Meishan earthquake, the region close to the Yangshuigang earthquake epicenter had a +0.75 bar stress increase. The results indicated significant interaction between the three damage events. Considering the path and site effect using ground motion prediction equations, a probabilistic seismic hazard in the form of a hazard evolution and a hazard map was assessed. A significant elevation in hazards following the three earthquakes in the sequence was determined. The results illustrate a possible scenario for seismic hazards in the Chiayi region which may take place repeatly in the future. Such scenario provides essential information on earthquake preparation, devastation estimations, emergency sheltering, utility restoration, and structure reconstruction.