The 2016 ML 6.6 Meinong earthquake struck southern Taiwan and caused serious damage due to the strong ground shaking. Since the spatiotemporal signatures of anomalous seismicity change prior to the 2010 Jiashian event was found, we want to investigate seismicity rate changes associated with the 2016 Meinong mainshock by applying the region-time-length (RTL) algorithm. Temporal result reveals a long obvious seismic quiescence stage soon after the 2012 Wutai event till the occurrence of the 2016 Meinong mainshock. In addition, the spatial pattern of different background period lengths all exhibit that the 2016 Meinong event occurred near the abnormal seismic quiescence patch. Our study shows that the spatiotemporal information of the seismicity change could be useful hint for potential seismic-hazard assessment.